SIRT3 protects against early brain injury following subarachnoid hemorrhage via promoting mitochondrial fusion in an AMPK dependent manner

SIRT3 protects against early brain injury following subarachnoid hemorrhage via promoting mitochondrial fusion in an AMPK dependent manner

Abstract Background Subarachnoid hemorrhage (SAH), an acute cerebrovascular accident, features with its high death and disability rate. Sirtuin3 (SIRT3) is a NAD+ dependent deacetylase which mainly located in mitochondria. Reduced SIRT3 function was indicated to involve in many disorders of central...

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Bibliographic Details
Main Authors: Xun Wu, Jianing Luo, Haixiao Liu, Wenxing Cui, Dayun Feng, Yan Qu
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Chinese Neurosurgical Journal
Subjects:
Subarachnoid hemorrhage
SIRT3
Honokiol
Mitochondrial fusion
AMPK
Mfn1
Online Access:https://doi.org/10.1186/s41016-019-0182-7

Internet

https://doi.org/10.1186/s41016-019-0182-7

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