Deciphering cancer cell state plasticity with single-cell genomics and artificial intelligence

Abstract Cancer stem cell plasticity refers to the ability of tumour cells to dynamically switch between states—for example, from cancer stem cells to non-cancer stem cell states. Governed by regulatory processes, cells transition through a continuum, with this transition space often referred to as...

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Bibliographic Details
Main Authors: Emily Holton, Walter Muskovic, Joseph E Powell
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Genome Medicine
Online Access:https://doi.org/10.1186/s13073-024-01309-4