RAC3 Inhibition Induces Autophagy to Impair Metastasis in Bladder Cancer Cells via the PI3K/AKT/mTOR Pathway

RAC3 Inhibition Induces Autophagy to Impair Metastasis in Bladder Cancer Cells via the PI3K/AKT/mTOR Pathway

BackgroundBladder cancer (BCa) is one of the most frequent malignant tumors globally, with a significant morbidity and mortality rate. Gene expression dysregulation has been proven to play a critical role in tumorigenesis. Ras-related C3 botulinum toxin substrate3 (RAC3), which is overexpressed in s...

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Bibliographic Details
Main Authors: Liwei Wang, Jiazhong Shi, Sha Liu, Yaqin Huang, Hua Ding, Baixiong Zhao, Yuting Liu, Wuxing Wang, Jin Yang, Zhiwen Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
bladder cancer
RAC3
autophagy
metastasis
PI3K/AKT/mTOR
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.915240/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.915240/full

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