Role of the mucin-like glycoprotein FCGBP in mucosal immunity and cancer
IgGFc-binding protein (FCGBP) is a mucin first detected in the intestinal epithelium. It plays an important role in innate mucosal epithelial defense, tumor metastasis, and tumor immunity. FCGBP forms disulfide-linked heterodimers with mucin-2 and members of the trefoil factor family. These formed c...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-07-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.863317/full |
| _version_ | 1818190772155973632 |
|---|---|
| author | Qiao Liu Xia Niu Yang Li Jia-rui Zhang Shao-jun Zhu Qi-yuan Yang Wei Zhang Li Gong |
| author_facet | Qiao Liu Xia Niu Yang Li Jia-rui Zhang Shao-jun Zhu Qi-yuan Yang Wei Zhang Li Gong |
| author_sort | Qiao Liu |
| collection | DOAJ |
| description | IgGFc-binding protein (FCGBP) is a mucin first detected in the intestinal epithelium. It plays an important role in innate mucosal epithelial defense, tumor metastasis, and tumor immunity. FCGBP forms disulfide-linked heterodimers with mucin-2 and members of the trefoil factor family. These formed complexes inhibit bacterial attachment to mucosal surfaces, affect the motility of pathogens, and support their clearance. Altered FCGBP expression levels may be important in the pathologic processes of Crohn’s disease and ulcerative colitis. FCGBP is also involved in regulating the infiltration of immune cells into tumor microenvironments. Thus, the molecule is a valuable marker of tumor prognosis. This review summarizes the functional relevance and role of FCGBP in immune responses and disease development, and highlights the potential role in diagnosis and predicting tumor prognosis. |
| first_indexed | 2024-12-12T00:04:01Z |
| format | Article |
| id | doaj.art-77fec957261c45a6a56f01c0a76d0b9e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T00:04:01Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-77fec957261c45a6a56f01c0a76d0b9e2022-12-22T00:45:09ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-07-011310.3389/fimmu.2022.863317863317Role of the mucin-like glycoprotein FCGBP in mucosal immunity and cancerQiao Liu0Xia Niu1Yang Li2Jia-rui Zhang3Shao-jun Zhu4Qi-yuan Yang5Wei Zhang6Li Gong7Department of Pathology, The Second Affiliated Hospital of Air Force Medical University, Xi’an, ChinaDepartment of Pathology, The Second Affiliated Hospital of Air Force Medical University, Xi’an, ChinaCollege of Animal Science and Technology, Northwest A&F University, Yangling, ChinaDepartment of Pathology, The Second Affiliated Hospital of Air Force Medical University, Xi’an, ChinaDepartment of Pathology, The Second Affiliated Hospital of Air Force Medical University, Xi’an, ChinaDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, United StatesDepartment of Pathology, The Second Affiliated Hospital of Air Force Medical University, Xi’an, ChinaDepartment of Pathology, The Second Affiliated Hospital of Air Force Medical University, Xi’an, ChinaIgGFc-binding protein (FCGBP) is a mucin first detected in the intestinal epithelium. It plays an important role in innate mucosal epithelial defense, tumor metastasis, and tumor immunity. FCGBP forms disulfide-linked heterodimers with mucin-2 and members of the trefoil factor family. These formed complexes inhibit bacterial attachment to mucosal surfaces, affect the motility of pathogens, and support their clearance. Altered FCGBP expression levels may be important in the pathologic processes of Crohn’s disease and ulcerative colitis. FCGBP is also involved in regulating the infiltration of immune cells into tumor microenvironments. Thus, the molecule is a valuable marker of tumor prognosis. This review summarizes the functional relevance and role of FCGBP in immune responses and disease development, and highlights the potential role in diagnosis and predicting tumor prognosis.https://www.frontiersin.org/articles/10.3389/fimmu.2022.863317/fullmucosal immunityMUC2FCGBPTFF familySARS-CoV-2EMT |
| spellingShingle | Qiao Liu Xia Niu Yang Li Jia-rui Zhang Shao-jun Zhu Qi-yuan Yang Wei Zhang Li Gong Role of the mucin-like glycoprotein FCGBP in mucosal immunity and cancer Frontiers in Immunology mucosal immunity MUC2 FCGBP TFF family SARS-CoV-2 EMT |
| title | Role of the mucin-like glycoprotein FCGBP in mucosal immunity and cancer |
| title_full | Role of the mucin-like glycoprotein FCGBP in mucosal immunity and cancer |
| title_fullStr | Role of the mucin-like glycoprotein FCGBP in mucosal immunity and cancer |
| title_full_unstemmed | Role of the mucin-like glycoprotein FCGBP in mucosal immunity and cancer |
| title_short | Role of the mucin-like glycoprotein FCGBP in mucosal immunity and cancer |
| title_sort | role of the mucin like glycoprotein fcgbp in mucosal immunity and cancer |
| topic | mucosal immunity MUC2 FCGBP TFF family SARS-CoV-2 EMT |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.863317/full |
| work_keys_str_mv | AT qiaoliu roleofthemucinlikeglycoproteinfcgbpinmucosalimmunityandcancer AT xianiu roleofthemucinlikeglycoproteinfcgbpinmucosalimmunityandcancer AT yangli roleofthemucinlikeglycoproteinfcgbpinmucosalimmunityandcancer AT jiaruizhang roleofthemucinlikeglycoproteinfcgbpinmucosalimmunityandcancer AT shaojunzhu roleofthemucinlikeglycoproteinfcgbpinmucosalimmunityandcancer AT qiyuanyang roleofthemucinlikeglycoproteinfcgbpinmucosalimmunityandcancer AT weizhang roleofthemucinlikeglycoproteinfcgbpinmucosalimmunityandcancer AT ligong roleofthemucinlikeglycoproteinfcgbpinmucosalimmunityandcancer |