Role of the mucin-like glycoprotein FCGBP in mucosal immunity and cancer

Role of the mucin-like glycoprotein FCGBP in mucosal immunity and cancer

IgGFc-binding protein (FCGBP) is a mucin first detected in the intestinal epithelium. It plays an important role in innate mucosal epithelial defense, tumor metastasis, and tumor immunity. FCGBP forms disulfide-linked heterodimers with mucin-2 and members of the trefoil factor family. These formed c...

Full description

Bibliographic Details
Main Authors:	Qiao Liu, Xia Niu, Yang Li, Jia-rui Zhang, Shao-jun Zhu, Qi-yuan Yang, Wei Zhang, Li Gong
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-07-01
Series:	Frontiers in Immunology
Subjects:	mucosal immunity MUC2 FCGBP TFF family SARS-CoV-2 EMT
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.863317/full

Similar Items

Expression Profiling along the Murine Intestine: Different Mucosal Protection Systems and Alterations in <i>Tff1</i>-Deficient Animals
by: Franz Salm, et al.
Published: (2023-08-01)

Different Forms of TFF3 in the Human Endocervix, including a Complex with IgG Fc Binding Protein (FCGBP), and Further Aspects of the Cervico-Vaginal Innate Immune Barrier
by: Aikaterini Laskou, et al.
Published: (2024-02-01)

IgGFc-binding protein and MUC2 mucin produced by colonic goblet-like cells spatially interact non-covalently and regulate wound healing
by: Hayley Gorman, et al.
Published: (2023-06-01)

Different Molecular Forms of TFF3 in the Human Respiratory Tract: Heterodimerization with IgG Fc Binding Protein (FCGBP) and Proteolytic Cleavage in Bronchial Secretions
by: Jens Weste, et al.
Published: (2022-12-01)

Salivary Trefoil Factor Family (TFF) Peptides and Their Roles in Oral and Esophageal Protection: Therapeutic Potential
by: Werner Hoffmann
Published: (2021-11-01)

FCGBP Is a Prognostic Biomarker and Associated With Immune Infiltration in Glioma
by: Tengfeng Yan, et al.
Published: (2022-01-01)

The Tumor Suppressor TFF1 Occurs in Different Forms and Interacts with Multiple Partners in the Human Gastric Mucus Barrier: Indications for Diverse Protective Functions
by: Jörn Heuer, et al.
Published: (2020-04-01)

Multi-Omics Analyses to Identify FCGBP as a Potential Predictor in Head and Neck Squamous Cell Carcinoma
by: Yu-Hsuan Lin, et al.
Published: (2022-05-01)

Validation of the DNA Methylation Landscape of TFF1/TFF2 in Gastric Cancer
by: Ze Qian, et al.
Published: (2022-11-01)

Eubacterium coprostanoligenes alleviates chemotherapy-induced intestinal mucositis by enhancing intestinal mucus barrier
by: Dongsheng Bai, et al.
Published: (2024-04-01)

Development of New Models of Oral Mucosa to Investigate the Impact of the Structure of Transmembrane Mucin-1 on the Mucosal Pellicle Formation and Its Physicochemical Properties
by: Clément Nivet, et al.
Published: (2024-01-01)

Defensive Properties of Mucin Glycoproteins during Respiratory Infections—Relevance for SARS-CoV-2
by: Maitrayee Chatterjee, et al.
Published: (2020-12-01)

Tepotinib Inhibits the Epithelial–Mesenchymal Transition and Tumor Growth of Gastric Cancers by Increasing GSK3β, E-Cadherin, and Mucin 5AC and 6 Levels
by: Sung-Hwa Sohn, et al.
Published: (2020-08-01)

Trefoil Factor 3 Protein and Sepsis
by: Iva Bazina, et al.
Published: (2022-11-01)

Associations between the expression of mucins (MUC1, MUC2, MUC5AC and MUC6) and clinicopathologic parameters of human breast carcinomas
by: Onur Oral, et al.
Published: (2020-01-01)

The Relation between Red Meat and Whole-Grain Intake and the Colonic Mucosal Barrier: A Cross-Sectional Study
by: Mohamad Jawhara, et al.
Published: (2020-06-01)

Mechanistic and Functional Shades of Mucins and Associated Glycans in Colon Cancer
by: Ramesh Pothuraju, et al.
Published: (2020-03-01)

A Novel Prognostic Marker and Therapeutic Target Associated with Glioma Progression in a Tumor Immune Microenvironment
by: Zhang JJ, et al.
Published: (2023-03-01)

NICD3 regulates the expression of MUC5AC and MUC2 by recruiting SMARCA4 and is involved in the differentiation of mucinous colorectal adenocarcinoma
by: Xiaodong Yan, et al.
Published: (2022-10-01)

Mucinous colorectal adenocarcinoma: clinical pathology and treatment options
by: Cong Luo, et al.
Published: (2019-03-01)

The Effect of Endotoxin on the Intestinal Mucus Layer in Non- and Post-pregnancy Mice
by: Dujian Yan, et al.
Published: (2022-02-01)

Production of Intestinal Mucins, sIgA, and Metallothionein after Administration of Zinc and Infection of <em>Ascaridia galli</em> in Chickens: Preliminary Data
by: Martin Levkut, et al.
Published: (2022-12-01)

Trefoil Factor Family (TFF): Peptides with Numerous Functions
by: Nataša Kozina, et al.
Published: (2019-05-01)

Tff3 is Expressed in Neurons and Microglial Cells
by: Ting Fu, et al.
Published: (2014-11-01)

Under the Hood: Understanding the Features of Mucin in Pseudomyxoma Peritonei
by: Pedro Villarejo-Campos, et al.
Published: (2023-06-01)

The Forms of the Lectin Tff2 Differ in the Murine Stomach and Pancreas: Indications for Different Molecular Functions
by: Eva B. Znalesniak, et al.
Published: (2023-04-01)

Mucin1 and Mucin16: Therapeutic Targets for Cancer Therapy
by: Dong-Hee Lee, et al.
Published: (2021-10-01)

A randomized, double-blind, placebo-controlled phase I trial of inhalation treatment of recombinant TFF2-IFN protein: A multifunctional candidate for the treatment of COVID-19
by: Yan Liu, et al.
Published: (2022-12-01)

Muc2 Mucin and Nonmucin Microbiota Confer Distinct Innate Host Defense in Disease Susceptibility and Colonic InjurySummary
by: Aralia Leon-Coria, et al.
Published: (2021-01-01)

Mucin-Type O-Glycans: Barrier, Microbiota, and Immune Anchors in Inflammatory Bowel Disease
by: Zhang Y, et al.
Published: (2021-11-01)

Mucin phenotype of differentiated early gastric cancer: an immunohistochemistry study supporting therapeutic decision making
by: Cavalcanti E, et al.
Published: (2019-06-01)

Trefoil Factor Family (TFF) Modules Are Characteristic Constituents of Separate Mucin Complexes in the <i>Xenopus laevis</i> Integumentary Mucus: In Vitro Binding Studies with FIM-A.1
by: René Stürmer, et al.
Published: (2020-03-01)

Prognostic significance of muc4 expression in gallbladder carcinoma
by: Lee Hyeon, et al.
Published: (2012-10-01)

The Roles of Transmembrane Mucins Located on Chromosome 7q22.1 in Colorectal Cancer
by: Almasmoum H
Published: (2021-04-01)

The Biological Synthesis and the Function of Mucin 2 in Pseudomyxoma Peritonei
by: Lin YL, et al.
Published: (2021-10-01)

Zinc Deficiency Disturbs Mucin Expression, <i>O</i>-Glycosylation and Secretion by Intestinal Goblet Cells
by: Maria Maares, et al.
Published: (2020-08-01)

Mucin Glycans: A Target for Cancer Therapy
by: Lingbo Sun, et al.
Published: (2023-10-01)

A clinical pilot study on the safety and efficacy of aerosol inhalation treatment of IFN-κ plus TFF2 in patients with moderate COVID-19
by: Weihui Fu, et al.
Published: (2020-08-01)

Upregulation of cell-surface mucin MUC15 in human nasal epithelial cells upon influenza A virus infection
by: Zhuang Gui Chen, et al.
Published: (2019-07-01)

The role of crude saliva and purified salivary mucins in the inhibition of the Human Immunodeficiency Virus type 1
by: Peacocke Julia, et al.
Published: (2012-08-01)