ESX Secretion-Associated Protein C From Mycobacterium tuberculosis Induces Macrophage Activation Through the Toll-Like Receptor-4/Mitogen-Activated Protein Kinase Signaling Pathway

ESX Secretion-Associated Protein C From Mycobacterium tuberculosis Induces Macrophage Activation Through the Toll-Like Receptor-4/Mitogen-Activated Protein Kinase Signaling Pathway

Mycobacterium tuberculosis, as a facultative intracellular pathogen, can interact with host macrophages and modulate macrophage function to influence innate and adaptive immunity. Proteins secreted by the ESX-1 secretion system are involved in this relationship. Although the importance of ESX-1 in h...

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Bibliographic Details
Main Authors: Qinglong Guo, Jing Bi, Ming Li, Wenxue Ge, Ying Xu, Weixing Fan, Honghai Wang, Xuelian Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Mycobacterium tuberculosis
ESX secretion-associated protein C
macrophage activation
Toll-like receptor 4
mitogen-activated protein kinase
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00158/full

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00158/full

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