CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development

Summary: CCR4-NOT deadenylase is a major regulator of mRNA turnover. It contains two heterogeneous catalytic subunits CNOT7/8 and CNOT6/6L in vertebrates. The physiological function of each catalytic subunit is unclear due to the gene redundancy. In this study, Cnot6/6l double knockout mice are gene...

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Bibliographic Details
Main Authors: Xing-Xing Dai, Zhi-Yan Jiang, Yun-Wen Wu, Qian-Qian Sha, Yang Liu, Jia-Yi Ding, Wen-Dong Xi, Jing Li, Heng-Yu Fan
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721014856