GTP binding protein 2 maintains the quiescence, self-renewal, and chemoresistance of mouse colorectal cancer stem cells via promoting Wnt signaling activation

GTP binding protein 2 maintains the quiescence, self-renewal, and chemoresistance of mouse colorectal cancer stem cells via promoting Wnt signaling activation

Colorectal cancer (CRC) is one of the most common cancers and the second most deadly cancer across the globe. Colorectal cancer stem cells (CCSCs) fuel CRC growth, metastasis, relapse, and chemoresistance. A complete understanding of the modulatory mechanisms of CCSC biology is essential for develop...

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Bibliographic Details
Main Authors: Chao Ke, Hongjian Zhou, Tian Xia, Xingwang Xie, Bin Jiang
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Heliyon
Subjects:
Colorectal cancer stem cells
GTP binding protein 2
Proliferation
Self-renewal
Chemoresistance
Stemness
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024031906

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http://www.sciencedirect.com/science/article/pii/S2405844024031906

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