Tracking the time course of pathological patterns of lung injury in severe COVID-19

Abstract Background Pulmonary involvement in COVID-19 is characterized pathologically by diffuse alveolar damage (DAD) and thrombosis, leading to the clinical picture of Acute Respiratory Distress Syndrome. The direct action of SARS-CoV-2 in lung cells and the dysregulated immuno-coagulative pathway...

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Bibliographic Details
Main Authors: Thais Mauad, Amaro Nunes Duarte-Neto, Luiz Fernando Ferraz da Silva, Ellen Pierre de Oliveira, Jose Mara de Brito, Ellen Caroline Toledo do Nascimento, Renata Aparecida de Almeida Monteiro, Juliana Carvalho Ferreira, Carlos Roberto Ribeiro de Carvalho, Paulo Hilário do Nascimento Saldiva, Marisa Dolhnikoff
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Respiratory Research
Subjects:
Online Access:https://doi.org/10.1186/s12931-021-01628-9