SARS-CoV-2 Spike-Specific CD4+ T Cell Response Is Conserved Against Variants of Concern, Including Omicron

SARS-CoV-2 Spike-Specific CD4+ T Cell Response Is Conserved Against Variants of Concern, Including Omicron

Although accumulating data have investigated the effect of SARS-CoV-2 mutations on antibody neutralizing activity, less is known about T cell immunity. In this work, we found that the ancestral (Wuhan strain) Spike protein can efficaciously reactivate CD4+ T cell memory in subjects with previous Alp...

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Bibliographic Details
Main Authors: Alessio Mazzoni, Anna Vanni, Michele Spinicci, Manuela Capone, Giulia Lamacchia, Lorenzo Salvati, Marco Coppi, Alberto Antonelli, Alberto Carnasciali, Parham Farahvachi, Nicla Giovacchini, Noemi Aiezza, Francesca Malentacchi, Lorenzo Zammarchi, Francesco Liotta, Gian Maria Rossolini, Alessandro Bartoloni, Lorenzo Cosmi, Laura Maggi, Francesco Annunziato
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
CD4
T cells
variants of concern (VOCs)
cellular immunity
vaccination
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.801431/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.801431/full

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