Hypoxia-induced loss of SRSF2-dependent DNA methylation promotes CTCF-mediated alternative splicing of VEGFA in breast cancer

Hypoxia-induced loss of SRSF2-dependent DNA methylation promotes CTCF-mediated alternative splicing of VEGFA in breast cancer

Summary: Alternative splicing of vascular endothelial growth factor A (VEGFA) generates numerous isoforms with unique roles in tumor angiogenesis, and investigating the underlying mechanism during hypoxia necessitates diligent pursuance. Our research systematically demonstrated that the splicing fac...

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Bibliographic Details
Main Authors: Pooja Yadav, Anchala Pandey, Parik Kakani, Srinivas Abhishek Mutnuru, Atul Samaiya, Jharna Mishra, Sanjeev Shukla
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:iScience
Subjects:
Biological sciences
Molecular mechanism of gene regulation
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223008817

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http://www.sciencedirect.com/science/article/pii/S2589004223008817

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