Evaluation of Toxicity Equivalency Factors of Tetrodotoxin Analogues with a Neuro-2a Cell-Based Assay and Application to Puffer Fish from Greece

Evaluation of Toxicity Equivalency Factors of Tetrodotoxin Analogues with a Neuro-2a Cell-Based Assay and Application to Puffer Fish from Greece

Tetrodotoxin (TTX) is a potent marine neurotoxin involved in poisoning cases, especially through the consumption of puffer fish. Knowledge of the toxicity equivalency factors (TEFs) of TTX analogues is crucial in monitoring programs to estimate the toxicity of samples analyzed with instrumental anal...

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Bibliographic Details
Main Authors: Mounira Alkassar, Andres Sanchez-Henao, Jaume Reverté, Lourdes Barreiro, Maria Rambla-Alegre, Sandra Leonardo, Manolis Mandalakis, Panagiota Peristeraki, Jorge Diogène, Mònica Campàs
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Marine Drugs
Subjects:
tetrodotoxin (TTX)
TTX analogue
toxicity equivalency factor (TEF)
cell-based assay (CBA)
liquid chromatography-tandem mass spectrometry (LC-MS/MS)
puffer fish
Online Access:https://www.mdpi.com/1660-3397/21/8/432

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https://www.mdpi.com/1660-3397/21/8/432

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