Preparative Production of Functionalized (<i>N</i>- and <i>O</i>-Heterocyclic) Polycyclic Aromatic Hydrocarbons by Human Cytochrome P450 3A4 in a Bioreactor

Preparative Production of Functionalized (<i>N</i>- and <i>O</i>-Heterocyclic) Polycyclic Aromatic Hydrocarbons by Human Cytochrome P450 3A4 in a Bioreactor

Polycyclic aromatic hydrocarbons (PAHs) and their N- and O-containing derivatives (N-/O-PAHs) are environmental pollutants and synthetically attractive building blocks in pharmaceuticals. Functionalization of PAHs can be achieved via C-H activation by cytochrome P450 enzymes (e.g., P450 CYP3A4) in a...

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Bibliographic Details
Main Authors: Matic Srdič, Nico D. Fessner, Deniz Yildiz, Anton Glieder, Markus Spiertz, Ulrich Schwaneberg
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Biomolecules
Subjects:
cytochrome P450 3A4
CYP3A4
preparative-scale synthesis
PAHs
whole-cell biotransformation
bioreactor
Online Access:https://www.mdpi.com/2218-273X/12/2/153

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https://www.mdpi.com/2218-273X/12/2/153

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