CRISPR-powered quantitative keyword search engine in DNA data storage

Abstract Despite the growing interest of archiving information in synthetic DNA to confront data explosion, quantitatively querying the data stored in DNA is still a challenge. Herein, we present Search Enabled by Enzymatic Keyword Recognition (SEEKER), which utilizes CRISPR-Cas12a to rapidly genera...

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Bibliographic Details
Main Authors: Jiongyu Zhang, Chengyu Hou, Changchun Liu
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46767-x