Structural model for the interaction of a designed Ankyrin Repeat Protein with the human epidermal growth factor receptor 2.

Designed Ankyrin Repeat Proteins are a class of novel binding proteins that can be selected and evolved to bind to targets with high affinity and specificity. We are interested in the DARPin H10-2-G3, which has been evolved to bind with very high affinity to the human epidermal growth factor recepto...

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Bibliographic Details
Main Authors: V Chandana Epa, Olan Dolezal, Larissa Doughty, Xiaowen Xiao, Christian Jost, Andreas Plückthun, Timothy E Adams
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3602593?pdf=render