Combinations of the azaquinazoline anti-Wolbachia agent, AWZ1066S, with benzimidazole anthelmintics synergise to mediate sub-seven-day sterilising and curative efficacies in experimental models of filariasis

Combinations of the azaquinazoline anti-Wolbachia agent, AWZ1066S, with benzimidazole anthelmintics synergise to mediate sub-seven-day sterilising and curative efficacies in experimental models of filariasis

Lymphatic filariasis and onchocerciasis are two major neglected tropical diseases that are responsible for causing severe disability in 50 million people worldwide, whilst veterinary filariasis (heartworm) is a potentially lethal parasitic infection of companion animals. There is an urgent need for...

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Bibliographic Details
Main Authors: Shrilakshmi Hegde, Amy E. Marriott, Nicolas Pionnier, Andrew Steven, Christina Bulman, Emma Gunderson, Ian Vogel, Marianne Koschel, Alexandra Ehrens, Sara Lustigman, Denis Voronin, Nancy Tricoche, Achim Hoerauf, Marc P. Hübner, Judy Sakanari, Ghaith Aljayyoussi, Fabian Gusovsky, Jessica Dagley, David W. Hong, Paul O'Neill, Steven A. Ward, Mark J. Taylor, Joseph D. Turner
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Microbiology
Subjects:
lymphatic filariasis
Wolbachia
onchocerciasis
AWZ1066S
benzimidazole
macrofilaricidal drugs
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1346068/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2024.1346068/full

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