Lack of Neuroprotection with a Single Intravenous Infusion of Human Amnion Epithelial Cells after Severe Hypoxia–Ischemia in Near-Term Fetal Sheep

Lack of Neuroprotection with a Single Intravenous Infusion of Human Amnion Epithelial Cells after Severe Hypoxia–Ischemia in Near-Term Fetal Sheep

Background: Hypoxic–ischemic encephalopathy (HIE) around the time of birth results from loss of oxygen (hypoxia) and blood supply (ischemia). Exogenous infusion of multi-potential cells, including human amnion epithelial cells (hAECs), can reduce hypoxic–ischemic (HI) brain injury. However, there ar...

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Bibliographic Details
Main Authors: Joanne O. Davidson, Lotte G. van den Heuij, Simerdeep K. Dhillon, Suzanne L. Miller, Rebecca Lim, Graham Jenkin, Alistair J. Gunn, Laura Bennet
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
human amnion epithelial cells
hypoxia ischemia
neuroprotection
fetal sheep
inflammation
Online Access:https://www.mdpi.com/1422-0067/23/15/8393

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https://www.mdpi.com/1422-0067/23/15/8393

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