Amyloid-β Induces Cdh1-Mediated Rock2 Stabilization Causing Neurodegeneration

Amyloid-β Induces Cdh1-Mediated Rock2 Stabilization Causing Neurodegeneration

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline, which is causally related to the accumulation of abnormally folded amyloid-β (Aβ) peptide and hyperphosphorylated tau protein aggregates. The dendritic spine regulator Rho protein kinase 2 (Rock2...

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Bibliographic Details
Main Authors: Rebeca Lapresa, Jesus Agulla, Sonia Gonzalez-Guerrero, Juan P. Bolaños, Angeles Almeida
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
amyloid-β
CDK5
CDH1
ROCK2
neurodegenaration
Alzheimer’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.884470/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.884470/full

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