Structural insights into the functional diversity of the CDK–cyclin family
Since their characterization as conserved modules that regulate progression through the eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are now also emerging as significant regulators of transcription, metabolism and cell differentiation. The cyclins, though...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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The Royal Society
2018-09-01
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| Series: | Open Biology |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.180112 |
| _version_ | 1818884670703534080 |
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| author | Daniel J. Wood Jane A. Endicott |
| author_facet | Daniel J. Wood Jane A. Endicott |
| author_sort | Daniel J. Wood |
| collection | DOAJ |
| description | Since their characterization as conserved modules that regulate progression through the eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are now also emerging as significant regulators of transcription, metabolism and cell differentiation. The cyclins, though originally characterized as CDK partners, also have CDK-independent roles that include the regulation of DNA damage repair and transcriptional programmes that direct cell differentiation, apoptosis and metabolic flux. This review compares the structures of the members of the CDK and cyclin families determined by X-ray crystallography, and considers what mechanistic insights they provide to guide functional studies and distinguish CDK- and cyclin-specific activities. Aberrant CDK activity is a hallmark of a number of diseases, and structural studies can provide important insights to identify novel routes to therapy. |
| first_indexed | 2024-12-19T15:53:14Z |
| format | Article |
| id | doaj.art-78283468c0b240b89b8dd3b1bbb950bc |
| institution | Directory Open Access Journal |
| issn | 2046-2441 |
| language | English |
| last_indexed | 2024-12-19T15:53:14Z |
| publishDate | 2018-09-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Open Biology |
| spelling | doaj.art-78283468c0b240b89b8dd3b1bbb950bc2022-12-21T20:15:09ZengThe Royal SocietyOpen Biology2046-24412018-09-018910.1098/rsob.180112180112Structural insights into the functional diversity of the CDK–cyclin familyDaniel J. WoodJane A. EndicottSince their characterization as conserved modules that regulate progression through the eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are now also emerging as significant regulators of transcription, metabolism and cell differentiation. The cyclins, though originally characterized as CDK partners, also have CDK-independent roles that include the regulation of DNA damage repair and transcriptional programmes that direct cell differentiation, apoptosis and metabolic flux. This review compares the structures of the members of the CDK and cyclin families determined by X-ray crystallography, and considers what mechanistic insights they provide to guide functional studies and distinguish CDK- and cyclin-specific activities. Aberrant CDK activity is a hallmark of a number of diseases, and structural studies can provide important insights to identify novel routes to therapy.https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.180112cell cyclekinasecyclintranscription |
| spellingShingle | Daniel J. Wood Jane A. Endicott Structural insights into the functional diversity of the CDK–cyclin family Open Biology cell cycle kinase cyclin transcription |
| title | Structural insights into the functional diversity of the CDK–cyclin family |
| title_full | Structural insights into the functional diversity of the CDK–cyclin family |
| title_fullStr | Structural insights into the functional diversity of the CDK–cyclin family |
| title_full_unstemmed | Structural insights into the functional diversity of the CDK–cyclin family |
| title_short | Structural insights into the functional diversity of the CDK–cyclin family |
| title_sort | structural insights into the functional diversity of the cdk cyclin family |
| topic | cell cycle kinase cyclin transcription |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.180112 |
| work_keys_str_mv | AT danieljwood structuralinsightsintothefunctionaldiversityofthecdkcyclinfamily AT janeaendicott structuralinsightsintothefunctionaldiversityofthecdkcyclinfamily |