Characterization of the SGLT2 Interaction Network and Its Regulation by SGLT2 Inhibitors: A Bioinformatic Analysis

Characterization of the SGLT2 Interaction Network and Its Regulation by SGLT2 Inhibitors: A Bioinformatic Analysis

Background: Sodium–glucose cotransporter 2 (SGLT2), also known as solute carrier family 5 member 2 (SLC5A2), is a promising target for a new class of drugs primarily established as kidney-targeting, effective glucose-lowering agents used in diabetes mellitus (DM) patients. Increasing evidence indica...

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Bibliographic Details
Main Authors: Zofia Wicik, Anna Nowak, Joanna Jarosz-Popek, Marta Wolska, Ceren Eyileten, Jolanta M. Siller-Matula, Dirk von Lewinski, Harald Sourij, Krzysztof J. Filipiak‬, Marek Postuła
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
SGLT2
AMPK
mTOR
bioinformatic analysis
network
gene target interaction
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.901340/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.901340/full

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