Surface expression of the immunotherapeutic target GD2 in osteosarcoma depends on cell confluency

Surface expression of the immunotherapeutic target GD2 in osteosarcoma depends on cell confluency

Abstract Background Chimeric antigen receptor (CAR) T‐cell therapy of pediatric sarcomas is challenged by the paucity of targetable cell surface antigens. A candidate target in osteosarcoma (OS) is the ganglioside GD2, but heterogeneous expression of GD2 limits its value. Aim We aimed to identify me...

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Bibliographic Details
Main Authors: Malena Wiebel, Sareetha Kailayangiri, Bianca Altvater, Jutta Meltzer, Kay Grobe, Sabine Kupich, Claudia Rossig
Format: Article
Language:English
Published: Wiley 2021-10-01
Series:Cancer Reports
Subjects:
cellular immunotherapy
chimeric antigen receptors
gangliosides
GD2
osteosarcoma
Online Access:https://doi.org/10.1002/cnr2.1394

Internet

https://doi.org/10.1002/cnr2.1394

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