Identification of platelet-activating factor as the inflammatory lipid mediator in CCl4-metabolizing rat liver

Identification of platelet-activating factor as the inflammatory lipid mediator in CCl4-metabolizing rat liver

Unmitigated oxidative stress is deleterious, as epitomized by CCl4 intoxication. In this well-characterized model of free radical-initiated damage, liver metabolism of CCl4 to CCl3. causes lipid peroxidation, F-ring isoprostane formation, and pathologic leukocyte activation. The nature of the mediat...

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Bibliographic Details
Main Authors: Gopal K. Marathe, Kathleen A. Harrison, L. Jackson Roberts, II, Jason D. Morrow, Robert C. Murphy, Larry W. Tjoelker, Stephen M. Prescott, Guy A. Zimmerman, Thomas M. McIntyre
Format: Article
Language:English
Published: Elsevier 2001-04-01
Series:Journal of Lipid Research
Subjects:
PAF
inflammation
liver
isoprostane
oxidation
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520303783

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http://www.sciencedirect.com/science/article/pii/S0022227520303783

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