The novel estrogen receptor modulator STX attenuates Amyloid-β neurotoxicity in the 5XFAD mouse model of Alzheimer's disease

The novel estrogen receptor modulator STX attenuates Amyloid-β neurotoxicity in the 5XFAD mouse model of Alzheimer's disease

Based on previous evidence that the non-steroidal estrogen receptor modulator STX mitigates the effects of neurotoxic Amyloid-β (Aβ) in vitro, we have evaluated its neuroprotective benefits in a mouse model of Alzheimer's disease. Cohorts of 5XFAD mice, which begin to accumulate cerebral Aβ at...

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Bibliographic Details
Main Authors: Joseph F. Quinn, Martin J. Kelly, Christopher J. Harris, Wyatt Hack, Nora E. Gray, Veronika Kulik, Zoe Bostick, Barbara H. Brumbach, Philip F. Copenhaver
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Neurobiology of Disease
Subjects:
Amyloid
Alzheimer's
Estrogen
Mitochondria
Reactive astrocytosis
Microgliosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122002807

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http://www.sciencedirect.com/science/article/pii/S0969996122002807

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