Troxerutin Prevents 5-Fluorouracil Induced Morphological Changes in the Intestinal Mucosa: Role of Cyclooxygenase-2 Pathway

Troxerutin Prevents 5-Fluorouracil Induced Morphological Changes in the Intestinal Mucosa: Role of Cyclooxygenase-2 Pathway

Intestinal mucositis is a common complication associated with 5-fluorouracil (5-FU), a chemotherapeutic agent used for cancer treatment. Troxerutin (TRX), a semi-synthetic flavonoid extracted from <i>Dimorphandra gardneriana</i>, has been reported as a potent antioxidant and anti-inflamm...

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Bibliographic Details
Main Authors: João Antônio Leal de Miranda, Conceição da Silva Martins, Lázaro de Sousa Fideles, Maria Lucianny Lima Barbosa, João Erivan Façanha Barreto, Helder Bindá Pimenta, Francisco Orlando Rafael Freitas, Paulo Vitor de Souza Pimentel, Claudio Silva Teixeira, Ariel Gustavo Scafuri, Maria Claudia dos Santos Luciano, Joabe Lima Araújo, Jefferson Almeida Rocha, Icaro Gusmão Pinto Vieira, Nágila Maria Pontes Silva Ricardo, Matheus da Silva Campelo, Maria Elenir Nobre Pinho Ribeiro, Gerly Anne de Castro Brito, Gilberto Santos Cerqueira
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Pharmaceuticals
Subjects:
chemoprevention
inflammation
flavonoid
intestine
Online Access:https://www.mdpi.com/1424-8247/13/1/10

Internet

https://www.mdpi.com/1424-8247/13/1/10

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