Soft TCPTP agonism – Novel target to rescue airway epithelial integrity by exogenous spermidine

Soft TCPTP agonism – Novel target to rescue airway epithelial integrity by exogenous spermidine

A reparative approach of disrupted epithelium in obstructive airway diseases, namely asthma and chronic obstructive pulmonary disease (COPD), may afford protection and long-lasting results compared to conventional therapies, e.g. corticosteroids or immunosuppressant drugs. Here we propose the polyam...

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Bibliographic Details
Main Authors: Carlo eGhisalberti, Rosa Maria eBorzì, Silvia eCetrullo, Flavio eFlamigni, Gaetano eCairo
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-06-01
Series:Frontiers in Pharmacology
Subjects:
Autophagy
Spermidine
TGF
Fgf
Epithelial to Mesenchymal transition
Key-words: TCPTP
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00147/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00147/full

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