Protein tyrosine phosphatase PTPRO represses lung adenocarcinoma progression by inducing mitochondria-dependent apoptosis and restraining tumor metastasis

Abstract Emerging evidence indicates that protein activities regulated by receptor protein tyrosine phosphatases (RPTPs) are crucial for a variety of cellular processes, such as proliferation, apoptosis, and immunological response. Protein tyrosine phosphatase receptor type O (PTPRO), an RPTP, has b...

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Bibliographic Details
Main Authors: Yuan Dai, Shuangshuang Shi, Hongda Liu, Hong Zhou, Wenqiu Ding, Chenyang Liu, Linling Jin, Weiping Xie, Hui Kong, Qun Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06375-x