Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate

Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate

The cerebrospinal fluid-secreting choroid plexus needs a balanced level of canonical Wnt signaling. Here the authors show that if this signaling is over-activated, the choroid plexus loses its properties and function, and transforms to a neuronal identity.

Bibliographic Details
Main Authors: Arpan Parichha, Varun Suresh, Mallika Chatterjee, Aditya Kshirsagar, Lihi Ben-Reuven, Tsviya Olender, M. Mark Taketo, Velena Radosevic, Mihaela Bobic-Rasonja, Sara Trnski, Michael J. Holtzman, Nataša Jovanov-Milosevic, Orly Reiner, Shubha Tole
Format: Article
Language:English
Published: Nature Portfolio 2022-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-27602-z

Internet

https://doi.org/10.1038/s41467-021-27602-z

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