Effect of trimetazidine treatment on the transient outward potassium current of the left ventricular myocytes of rats with streptozotocin-induced type 1 diabetes mellitus

Effect of trimetazidine treatment on the transient outward potassium current of the left ventricular myocytes of rats with streptozotocin-induced type 1 diabetes mellitus

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Cardiovascular complications are a leading cause of mortality in patients with diabetes mellitus (DM). The present study was designed to investigate the effects of trimetazidine (TMZ), an anti-angina drug, on transient outward potassium current (Ito) remodeling in ventricular myocytes and the plasma...

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Bibliographic Details
Main Authors: Yu-luan Xiang, Li He, Jun Xiao, Shuang Xia, Song-bai Deng, Yun Xiu, Qiang She
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2012-03-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Transient outward K+ current
Free fatty acid
Trimetazidine
Diabetic cardiomyopathy
Channel protein
Ventricular myocytes
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000300004

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000300004

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