Designing Single-Molecule Magnets as Drugs with Dual Anti-Inflammatory and Anti-Diabetic Effects

Designing Single-Molecule Magnets as Drugs with Dual Anti-Inflammatory and Anti-Diabetic Effects

We have designed and synthesized two novel cobalt coordination compounds using bumetanide (bum) and indomethacin (ind) therapeutic agents. The anti-inflammatory effects of cobalt metal complexes with ind and bum were assayed in lipopolysaccharide stimulated RAW 264.7 macrophages by inhibition of nit...

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Bibliographic Details
Main Authors: Arturo Navas, Fatin Jannus, Belén Fernández, Javier Cepeda, Marta Medina O’Donnell, Luis Díaz-Ruiz, Cristina Sánchez-González, Juan Llopis, José M. Seco, E. Rufino-Palomares, José Antonio Lupiáñez, Santiago Gómez-Ruiz, José Luis Quiles, Maurizio Battino, Duane Choquesillo-Lazarte, Ana Belén Ruiz-Muelle, Ignacio Fernández, Fernando Reyes-Zurita, Antonio Rodríguez-Diéguez
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
bumetadine
indomethacin
cobalt
coordination compound
single-ion magnet
inflammatory
Online Access:https://www.mdpi.com/1422-0067/21/9/3146

Internet

https://www.mdpi.com/1422-0067/21/9/3146

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