Generating an MEIS1 homozygous knockout human embryonic stem cell line using the CRISPR/Cas9 system

Myeloid ecotropic viral integration site 1 (MEIS1) plays an essential role in the development of several embryonic organs, such as the central nervous system and eyes. To further investigate the role of MEIS1 in embryonic development, herein, we generated a MEIS1 homozygous knockout human embryonic...

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Bibliographic Details
Main Authors: Canwei Zhang, Yankun Yu, Fuxi Li, Xihong Lan, Li Wang
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506120303706