Pathophysiological Underpinnings of Extra-Motor Neurodegeneration in Amyotrophic Lateral Sclerosis: New Insights From Biomarker Studies

Pathophysiological Underpinnings of Extra-Motor Neurodegeneration in Amyotrophic Lateral Sclerosis: New Insights From Biomarker Studies

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) lie at opposing ends of a clinical, genetic, and neuropathological continuum. In the last decade, it has become clear that cognitive and behavioral changes in patients with ALS are more frequent than previously recogniz...

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Bibliographic Details
Main Authors: David Reyes-Leiva, Oriol Dols-Icardo, Sonia Sirisi, Elena Cortés-Vicente, Janina Turon-Sans, Noemi de Luna, Rafael Blesa, Olivia Belbin, Victor Montal, Daniel Alcolea, Juan Fortea, Alberto Lleó, Ricard Rojas-García, Ignacio Illán-Gala
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Neurology
Subjects:
amyotrophic lateral sclerosis (ALS)
neuroimage
cerebrospinal fluid (CSF)
biomarker (BM)
neuropathology
TDP-43 = TAR DNA-binding protein 43
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.750543/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2021.750543/full

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