A single nucleotide polymorphism associated with hepatitis C virus infections located in the distal region of the IL28B promoter influences NF-κB-mediated gene transcription.

A single nucleotide polymorphism associated with hepatitis C virus infections located in the distal region of the IL28B promoter influences NF-κB-mediated gene transcription.

Persistence of hepatitis C virus (HCV) infection is observed only in a subset of infected individuals and among them only some respond to treatment. Genome-wide association studies (GWAS) carried out around the world identified single nucleotide polymorphisms (SNPs) in the IL28B locus that are stron...

Full description

Bibliographic Details
Main Authors: Sreedhar Chinnaswamy, Snehajyoti Chatterjee, Ramachandran Boopathi, Shuvolina Mukherjee, Samsiddhi Bhattacharjee, Tapas K Kundu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3792970?pdf=render

Internet

http://europepmc.org/articles/PMC3792970?pdf=render

Similar Items