Misoprostol Inhibits Lipopolysaccharide-Induced Pro-inflammatory Cytokine Production by Equine Leukocytes

Pro-inflammatory cytokines including tumor necrosis factor α (TNFα), IL-1β, IL-6, and IL-8 are potent immune mediators that exacerbate multiple equine diseases such as sepsis and laminitis. Unfortunately, safe and effective cytokine-targeting therapies are lacking in horses; therefore, novel mechani...

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Bibliographic Details
Main Authors: Emily Medlin Martin, Kristen M. Messenger, Mary Katherine Sheats, Samuel L. Jones
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Veterinary Science
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fvets.2017.00160/full