Cholesterol-enriched membrane micro-domain deficiency induces doxorubicin resistance via promoting autophagy in breast cancer

Cholesterol-enriched membrane micro-domain deficiency induces doxorubicin resistance via promoting autophagy in breast cancer

Drug resistance has become one of the largest challenges for cancer chemotherapies. Under certain conditions, cancer cells hijack autophagy to cope with therapeutic stress, which largely undermines the chemo-therapeutic efficacy. Currently, biomarkers indicative of autophagy-derived drug resistance...

Full description

Bibliographic Details
Main Authors: Yin Shi, Zu Ye, Guang Lu, Naidi Yang, Jianbin Zhang, Liming Wang, Jianzhou Cui, Miguel A. del Pozo, Yihua Wu, Dajing Xia, Han-Ming Shen
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Oncolytics
Subjects:
autophagy
breast cancer
doxorubicin resistance
cholesterol-enriched membrane micro-domains
CAV1
VAMP3
Online Access:http://www.sciencedirect.com/science/article/pii/S237277052100142X

Internet

http://www.sciencedirect.com/science/article/pii/S237277052100142X

Similar Items