Antiproliferative Properties of a Few Auranofin-Related Gold(I) and Silver(I) Complexes in Leukemia Cells and their Interferences with the Ubiquitin Proteasome System

Antiproliferative Properties of a Few Auranofin-Related Gold(I) and Silver(I) Complexes in Leukemia Cells and their Interferences with the Ubiquitin Proteasome System

A group of triethylphosphine gold(I) and silver(I) complexes, structurally related to auranofin, were prepared and investigated as potential anticancer drug candidates. The antiproliferative properties of these metal compounds were assessed against two leukemia cell lines, i.e., CCRF-CEM and its mul...

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Bibliographic Details
Main Authors: Damiano Cirri, Tanja Schirmeister, Ean-Jeong Seo, Thomas Efferth, Lara Massai, Luigi Messori, Nicola Micale
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
auranofin
metal complexes
proteasome inhibition
leukemia cells
antiproliferative properties
Online Access:https://www.mdpi.com/1420-3049/25/19/4454

Internet

https://www.mdpi.com/1420-3049/25/19/4454

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