Antibodies to FXa and thrombin in patients with SLE differentially regulate C3 and C5 cleavage

Objectives The significance of antibodies directed against activated factor X (FXa) and thrombin (Thr) in patients with SLE and/or antiphospholipid syndrome (APS) is unknown. FXa and Thr are coregulated by antithrombin (AT) and activate complement. Therefore, we studied the ability of anti activated...

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Bibliographic Details
Main Authors: Anisur Rahman, Ian Giles, Chris Wincup, Bahar Artim-Esen, Thomas McDonnell, Charis Pericleous, Raj Amarnani, Ian Mackie, Carina Spicer, Hajar Jbari, Valentina A Spiteri
Format: Article
Language:English
Published: BMJ Publishing Group 2022-07-01
Series:Lupus Science and Medicine
Online Access:https://lupus.bmj.com/content/9/1/e000738.full