Antibodies to FXa and thrombin in patients with SLE differentially regulate C3 and C5 cleavage

Antibodies to FXa and thrombin in patients with SLE differentially regulate C3 and C5 cleavage

Objectives The significance of antibodies directed against activated factor X (FXa) and thrombin (Thr) in patients with SLE and/or antiphospholipid syndrome (APS) is unknown. FXa and Thr are coregulated by antithrombin (AT) and activate complement. Therefore, we studied the ability of anti activated...

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Bibliographic Details
Main Authors: Anisur Rahman, Ian Giles, Chris Wincup, Bahar Artim-Esen, Thomas McDonnell, Charis Pericleous, Raj Amarnani, Ian Mackie, Carina Spicer, Hajar Jbari, Valentina A Spiteri
Format: Article
Language:English
Published: BMJ Publishing Group 2022-07-01
Series:Lupus Science and Medicine
Online Access:https://lupus.bmj.com/content/9/1/e000738.full

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