Evaluating the potential of gold, silver, and silica nanoparticles to saturate mononuclear phagocytic system tissues under repeat dosing conditions

Evaluating the potential of gold, silver, and silica nanoparticles to saturate mononuclear phagocytic system tissues under repeat dosing conditions

Abstract Background As nanoparticles (NPs) become more prevalent in the pharmaceutical industry, questions have arisen from both industry and regulatory stakeholders about the long term effects of these materials. This study was designed to evaluate whether gold (10 nm), silver (50 nm), or silica (1...

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Bibliographic Details
Main Authors: James L. Weaver, Grainne A. Tobin, Taylor Ingle, Simona Bancos, David Stevens, Rodney Rouse, Kristina E. Howard, David Goodwin, Alan Knapton, Xiaohong Li, Katherine Shea, Sharron Stewart, Lin Xu, Peter L. Goering, Qin Zhang, Paul C. Howard, Jessie Collins, Saeed Khan, Kidon Sung, Katherine M. Tyner
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Particle and Fibre Toxicology
Subjects:
Durable nanoparticles
repeat dose
gold nanoparticles
silver nanoparticles
silica nanoparticles
Online Access:http://link.springer.com/article/10.1186/s12989-017-0206-4

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http://link.springer.com/article/10.1186/s12989-017-0206-4

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