Small and innovative molecules as new strategy to revert MDR

Small and innovative molecules as new strategy to revert MDR

MDR is a complex phenomenon principally due to the overexpression of some transmembrane proteins belonging to the ATP Binding Cassette (ABC) transporter family. Among these transporters, P-Glycoprotein (P-gp), is the mostly involved in MDR and its overexpression is the major cause of cancer therapy...

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Bibliographic Details
Main Authors: Laura eZinzi, Elena eCapparelli, Mariangela eCantore, Marialessandra eContino, Marcello eLeopoldo, Nicola Antonio Colabufo
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-01-01
Series:Frontiers in Oncology
Subjects:
P-gp
MDR
dual effect
multitarget drugs
MDR reverting activity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00002/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00002/full

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