Targeting USP-7 by a Novel Fluorinated 5-Pyrazolyl-Urea Derivative

Targeting USP-7 by a Novel Fluorinated 5-Pyrazolyl-Urea Derivative

The impact of innovative technologies on the target discovery has been employed here to characterize the interactome of STIRUR 41, a promising 3-fluoro-phenyl-5-pyrazolyl-urea derivative endowed with anti-cancer activity, on neuroblastoma-related cells. A drug affinity responsive target stability-ba...

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Bibliographic Details
Main Authors: Elva Morretta, Chiara Brullo, Raffaella Belvedere, Antonello Petrella, Andrea Spallarossa, Maria Chiara Monti
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
pyrazole derivative
DARTS
t-LIP-MRM
USP-7
neuroblastoma
molecular docking
Online Access:https://www.mdpi.com/1422-0067/24/11/9200

Internet

https://www.mdpi.com/1422-0067/24/11/9200

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