Immunopurification of pathological prion protein aggregates.

Immunopurification of pathological prion protein aggregates.

BACKGROUND:Prion diseases are fatal neurodegenerative disorders that can arise sporadically, be genetically inherited or acquired through infection. The key event in these diseases is misfolding of the cellular prion protein (PrP(C)) into a pathogenic isoform that is rich in beta-sheet structure. Th...

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Bibliographic Details
Main Authors: Emiliano Biasini, Laura Tapella, Susanna Mantovani, Matteo Stravalaci, Marco Gobbi, David A Harris, Roberto Chiesa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2773113?pdf=render

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http://europepmc.org/articles/PMC2773113?pdf=render

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