Simple combination of multiple somatic variant callers to increase accuracy

Abstract Publications comparing variant caller algorithms present discordant results with contradictory rankings. Caller performances are inconsistent and wide ranging, and dependent upon input data, application, parameter settings, and evaluation metric. With no single variant caller emerging as a...

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Bibliographic Details
Main Authors: Alexander J. Trevarton, Jeffrey T. Chang, W. Fraser Symmans
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-34925-y