Ubiquitin specific peptidase 37 and PCNA interaction promotes osteosarcoma pathogenesis by modulating replication fork progression

Ubiquitin specific peptidase 37 and PCNA interaction promotes osteosarcoma pathogenesis by modulating replication fork progression

Abstract Background Osteosarcoma is a type of bone cancer that predominantly affects young individuals, including children and adolescents. The disease progresses through heterogeneous genetic alterations, and patients often develop pulmonary metastases even after the primary tumors have been surgic...

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Bibliographic Details
Main Authors: Ravi Chauhan, Ashna Gupta, Lakshay Malhotra, Ajaz A. Bhat, Raj K. Pandita, Tariq Masoodi, Gunjan Dagar, Hana Q. Sadida, Sara K. Al-Marzooqi, Atul Batra, Sameer Bakhshi, Mehar Chand Sharma, Pranay Tanwar, Shah Alam Khan, Ethayathulla Abdul Samath, Shahab Uddin, Ammira S. Al-Shabeeb Akil, Mohammad Haris, Muzafar A. Macha, Tej K. Pandita, Mayank Singh
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Journal of Translational Medicine
Subjects:
Deubiquitinating enzymes
Ubiquitin specific protease 37
Proliferating cell nuclear antigen
Replication stress
Metastasis
Online Access:https://doi.org/10.1186/s12967-023-04126-2

Internet

https://doi.org/10.1186/s12967-023-04126-2

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