Automatic generation of alloreactivity-reduced donor lymphocytes and hematopoietic stem cells from the same mobilized apheresis product

Automatic generation of alloreactivity-reduced donor lymphocytes and hematopoietic stem cells from the same mobilized apheresis product

Abstract Introduction In vitro or in vivo depletion of alloreactive T cells can facilitate haplo-identical hematopoietic stem cell transplantation (HSCT). Very satisfactory transplant outcomes were thus reported for TCRαβ/CD19-depleted hematopoietic stem/progenitor cell (HSPC) grafts. The current se...

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Bibliographic Details
Main Authors: E. Wiercinska, P. Quade-Lyssy, C. Hümmer, J. Beifuß, K. Akarkach, C. Poppe, V. Olevska, J. Dzionek, H. Lahnor, A. Bosio, E. Papanikolaou, Halvard Bonig
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Translational Medicine
Subjects:
Haploidentical HSCT
TCRαβ/CD19-depleted graft
CD45RA-depleted DLI
GMP-compatible process
CliniMACS Prodigy
Online Access:https://doi.org/10.1186/s12967-023-04738-8

Internet

https://doi.org/10.1186/s12967-023-04738-8

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