Antioxidant mitoquinone ameliorates EtOH-LPS induced lung injury by inhibiting mitophagy and NLRP3 inflammasome activation

Antioxidant mitoquinone ameliorates EtOH-LPS induced lung injury by inhibiting mitophagy and NLRP3 inflammasome activation

Chronic ethanol abuse is a systemic disorder and a risk factor for acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD). However, the mechanisms involved are unknown. One explanation is that ethanol produces damaging reactive oxygen species (ROS) and disturbs t...

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Bibliographic Details
Main Authors: Wenhua Sang, Sha Chen, Lidan Lin, Nan Wang, Xiaoxia Kong, Jinyan Ye
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
acute lung injury
lipopolysaccharide
NLRP3 inflammasome
mitophagy
reactive oxygen species
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.973108/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.973108/full

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