Position of UNC-13 in the active zone regulates synaptic vesicle release probability and release kinetics
The presynaptic active zone proteins UNC-13/Munc13s are essential for synaptic vesicle (SV) exocytosis by directly interacting with SV fusion apparatus. An open question is how their association with active zones, hence their position to Ca2+ entry sites, regulates SV release. The N-termini of major...
Main Authors: | Keming Zhou, Tamara M Stawicki, Alexandr Goncharov, Yishi Jin |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2013-11-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/01180 |
Similar Items
-
UNC-13L, UNC-13S, and Tomosyn form a protein code for fast and slow neurotransmitter release in Caenorhabditis elegans
by: Zhitao Hu, et al.
Published: (2013-08-01) -
Rapid Integration of Multi-copy Transgenes Using Optogenetic Mutagenesis in Caenorhabditis elegans
by: Kentaro Noma, et al.
Published: (2018-06-01) -
Release-dependent feedback inhibition by a presynaptically localized ligand-gated anion channel
by: Seika Takayanagi-Kiya, et al.
Published: (2016-10-01) -
Identification of PSD-95 in the Postsynaptic Density Using MiniSOG and EM Tomography
by: Xiaobing Chen, et al.
Published: (2018-12-01) -
Control of neurotransmitter release by two distinct membrane-binding faces of the Munc13-1 C1C2B region
by: Marcial Camacho, et al.
Published: (2021-11-01)