Intracellularly Released Cholesterol from Polymer-Based Delivery Systems Alters Cellular Responses to Pneumolysin and Promotes Cell Survival

Intracellularly Released Cholesterol from Polymer-Based Delivery Systems Alters Cellular Responses to Pneumolysin and Promotes Cell Survival

Cholesterol is highly abundant within all human body cells and modulates critical cellular functions related to cellular plasticity, metabolism, and survival. The cholesterol-binding toxin pneumolysin represents an essential virulence factor of <i>Streptococcus pneumoniae</i> in establis...

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Bibliographic Details
Main Authors: Tobias Kammann, Jessica Hoff, Ilknur Yildirim, Blerina Shkodra, Tina Müller, Christine Weber, Markus H. Gräler, Ulrich A. Maus, James C. Paton, Mervyn Singer, Anja Traeger, Ulrich S. Schubert, Michael Bauer, Adrian T. Press
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Metabolites
Subjects:
drug delivery
cholesterol
nanoparticle
microparticle
pneumolysin
pneumonia
Online Access:https://www.mdpi.com/2218-1989/11/12/821

Internet

https://www.mdpi.com/2218-1989/11/12/821

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