Lymphatic Defects in Zebrafish <i>sox18</i> Mutants Are Exacerbated by Perturbed VEGFC Signaling, While Masked by Elevated <i>sox7</i> Expression

Lymphatic Defects in Zebrafish <i>sox18</i> Mutants Are Exacerbated by Perturbed VEGFC Signaling, While Masked by Elevated <i>sox7</i> Expression

Mutations in the transcription factor-coding gene <i>SOX18</i>, the growth factor-coding gene <i>VEGFC</i> and its receptor-coding gene <i>VEGFR3/FLT4</i> cause primary lymphedema in humans. In mammals, SOX18, together with COUP-TFII/NR2F2, activates the expressio...

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Bibliographic Details
Main Authors: Silvia Moleri, Sara Mercurio, Alex Pezzotta, Donatella D’Angelo, Alessia Brix, Alice Plebani, Giulia Lini, Marialaura Di Fuorti, Monica Beltrame
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Cells
Subjects:
Sox18
SoxF transcription factors
VEGFC
lymphatic development
zebrafish
Online Access:https://www.mdpi.com/2073-4409/12/18/2309

Internet

https://www.mdpi.com/2073-4409/12/18/2309

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