Choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial – the development of the DELTA2 guidance

Choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial – the development of the DELTA2 guidance

Abstract Background A key step in the design of a randomised controlled trial is the estimation of the number of participants needed. The most common approach is to specify a target difference in the primary outcome between the randomised groups and then estimate the corresponding sample size. The s...

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Bibliographic Details
Main Authors: William Sones, Steven A. Julious, Joanne C. Rothwell, Craig Robert Ramsay, Lisa V. Hampson, Richard Emsley, Stephen J. Walters, Catherine Hewitt, Martin Bland, Dean A. Fergusson, Jesse A. Berlin, Doug Altman, Luke David Vale, Jonathan Alistair Cook
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Trials
Subjects:
Target difference
Clinically important difference
Sample size
Guidance
Randomised trial
Effect size
Online Access:http://link.springer.com/article/10.1186/s13063-018-2887-x

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http://link.springer.com/article/10.1186/s13063-018-2887-x

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