TASK-2: a K2P K+ channel with complex regulation and diverse physiological functions

TASK-2: a K2P K+ channel with complex regulation and diverse physiological functions

TASK-2 (K2P5.1) is a two-pore domain K+ channel belonging to the TALK subgroup of the K2P family of proteins. TASK-2 has been shown to be activated by extra- and intracellular alkalinisation. Extra- and intracellular pH-sensors reside at arginine 224 and lysine 245 and might affect separate selectiv...

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Bibliographic Details
Main Authors: Luis Pablo Cid, Hugo A Roa-Rojas, Maria Isabel eNiemeyer, Wendy eGonzalez, Masatake eAraki, Kimi eAraki, Francisco eSepulveda
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-07-01
Series:Frontiers in Physiology
Subjects:
Chondrocytes
K2P channels
TASK-2 channel
Bicarbonate reabsorption
Central chemoception
Cell volume regulation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00198/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00198/full

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